HFE gene: Structure, function, mutations, and associated iron abnormalities

hfe gene mutations, iron overload and cryptogenic liver cirrhosis

HFE gene mutations and iron status of Brazilian blood donors.

Mutations of the HFE and TFR2 genes have been associated with iron overload. HFE and TFR2 mutations were assessed in blood donors, and the relationship with iron status was evaluated. Subjects (N = 542) were recruited at the Hemocentro da Santa Casa de São Paulo, São Paulo, Brazil. Iron status was not influenced by HFE mutations in women and was independent of blood donation frequency. In contr...

HFE Gene Mutations, Iron Overload and Cryptogenic Liver Cirrhosis

The diagnosis of cryptogenic cirrhosis is an exclusion diagnosis. It has become far less frequent over the last decades , but it still effects a significant number of patients. Many previously unknown chronic liver disease entities were described in the second half of the last century, including chronic viral hepatitis B, C and D, along with refined criteria for diagnosing autoimmune hepatitis ...

Colorectal cancer and HFE gene mutations.

ly. CD158a and b were not expressed by these cells. Natural killer activity was normal. This case report describes an unusual context for the development of persistent NK lymphocytosis, i.e. more than one year post-transplantation, after infectious episodes not unusual in transplantation. This patient differs from the 26 CD8–/CD4–/NKa+ cases reported by Scott et al.,2 since nearly all lymphocyt...

hfe gene mutations in cryptogenic cirrhosis patients